TLN2 (англ. Talin 2) – білок, який кодується однойменним геном, розташованим у людей на довгому плечі 15-ї хромосоми.[3] Довжина поліпептидного ланцюга білка становить 2 542 амінокислот, а молекулярна маса — 271 613[4].
Послідовність амінокислот
| 10
|
|
20
|
|
30
|
|
40
|
|
50
|
| MVALSLKICV
|
|
RHCNVVKTMQ
|
|
FEPSTAVYDA
|
|
CRVIRERVPE
|
|
AQTGQASDYG
|
| LFLSDEDPRK
|
|
GIWLEAGRTL
|
|
DYYMLRNGDI
|
|
LEYKKKQRPQ
|
|
KIRMLDGSVK
|
| TVMVDDSKTV
|
|
GELLVTICSR
|
|
IGITNYEEYS
|
|
LIQETIEEKK
|
|
EEGTGTLKKD
|
| RTLLRDERKM
|
|
EKLKAKLHTD
|
|
DDLNWLDHSR
|
|
TFREQGVDEN
|
|
ETLLLRRKFF
|
| YSDQNVDSRD
|
|
PVQLNLLYVQ
|
|
ARDDILNGSH
|
|
PVSFEKACEF
|
|
GGFQAQIQFG
|
| PHVEHKHKPG
|
|
FLDLKEFLPK
|
|
EYIKQRGAEK
|
|
RIFQEHKNCG
|
|
EMSEIEAKVK
|
| YVKLARSLRT
|
|
YGVSFFLVKE
|
|
KMKGKNKLVP
|
|
RLLGITKDSV
|
|
MRVDEKTKEV
|
| LQEWPLTTVK
|
|
RWAASPKSFT
|
|
LDFGEYQESY
|
|
YSVQTTEGEQ
|
|
ISQLIAGYID
|
| IILKKKQSKD
|
|
RFGLEGDEES
|
|
TMLEESVSPK
|
|
KSTILQQQFN
|
|
RTGKAEHGSV
|
| ALPAVMRSGS
|
|
SGPETFNVGS
|
|
MPSPQQQVMV
|
|
GQMHRGHMPP
|
|
LTSAQQALMG
|
| TINTSMHAVQ
|
|
QAQDDLSELD
|
|
SLPPLGQDMA
|
|
SRVWVQNKVD
|
|
ESKHEIHSQV
|
| DAITAGTASV
|
|
VNLTAGDPAD
|
|
TDYTAVGCAI
|
|
TTISSNLTEM
|
|
SKGVKLLAAL
|
| MDDEVGSGED
|
|
LLRAARTLAG
|
|
AVSDLLKAVQ
|
|
PTSGEPRQTV
|
|
LTAAGSIGQA
|
| SGDLLRQIGE
|
|
NETDERFQDV
|
|
LMSLAKAVAN
|
|
AAAMLVLKAK
|
|
NVAQVAEDTV
|
| LQNRVIAAAT
|
|
QCALSTSQLV
|
|
ACAKVVSPTI
|
|
SSPVCQEQLI
|
|
EAGKLVDRSV
|
| ENCVRACQAA
|
|
TTDSELLKQV
|
|
SAAASVVSQA
|
|
LHDLLQHVRQ
|
|
FASRGEPIGR
|
| YDQATDTIMC
|
|
VTESIFSSMG
|
|
DAGEMVRQAR
|
|
VLAQATSDLV
|
|
NAMRSDAEAE
|
| IDMENSKKLL
|
|
AAAKLLADST
|
|
ARMVEAAKGA
|
|
AANPENEDQQ
|
|
QRLREAAEGL
|
| RVATNAAAQN
|
|
AIKKKIVNRL
|
|
EVAAKQAAAA
|
|
ATQTIAASQN
|
|
AAVSNKNPAA
|
| QQQLVQSCKA
|
|
VADHIPQLVQ
|
|
GVRGSQAQAE
|
|
DLSAQLALII
|
|
SSQNFLQPGS
|
| KMVSSAKAAV
|
|
PTVSDQAAAM
|
|
QLSQCAKNLA
|
|
TSLAELRTAS
|
|
QKAHEACGPM
|
| EIDSALNTVQ
|
|
TLKNELQDAK
|
|
MAAVESQLKP
|
|
LPGETLEKCA
|
|
QDLGSTSKAV
|
| GSSMAQLLTC
|
|
AAQGNEHYTG
|
|
VAARETAQAL
|
|
KTLAQAARGV
|
|
AASTTDPAAA
|
| HAMLDSARDV
|
|
MEGSAMLIQE
|
|
AKQALIAPGD
|
|
AERQQRLAQV
|
|
AKAVSHSLNN
|
| CVNCLPGQKD
|
|
VDVALKSIGE
|
|
SSKKLLVDSL
|
|
PPSTKPFQEA
|
|
QSELNQAAAD
|
| LNQSAGEVVH
|
|
ATRGQSGELA
|
|
AASGKFSDDF
|
|
DEFLDAGIEM
|
|
AGQAQTKEDQ
|
| IQVIGNLKNI
|
|
SMASSKLLLA
|
|
AKSLSVDPGA
|
|
PNAKNLLAAA
|
|
ARAVTESINQ
|
| LITLCTQQAP
|
|
GQKECDNALR
|
|
ELETVKGMLD
|
|
NPNEPVSDLS
|
|
YFDCIESVME
|
| NSKVLGESMA
|
|
GISQNAKTGD
|
|
LPAFGECVGI
|
|
ASKALCGLTE
|
|
AAAQAAYLVG
|
| ISDPNSQAGH
|
|
QGLVDPIQFA
|
|
RANQAIQMAC
|
|
QNLVDPGSSP
|
|
SQVLSAATIV
|
| AKHTSALCNA
|
|
CRIASSKTAN
|
|
PVAKRHFVQS
|
|
AKEVANSTAN
|
|
LVKTIKALDG
|
| DFSEDNRNKC
|
|
RIATAPLIEA
|
|
VENLTAFASN
|
|
PEFVSIPAQI
|
|
SSEGSQAQEP
|
| ILVSAKTMLE
|
|
SSSYLIRTAR
|
|
SLAINPKDPP
|
|
TWSVLAGHSH
|
|
TVSDSIKSLI
|
| TSIRDKAPGQ
|
|
RECDYSIDGI
|
|
NRCIRDIEQA
|
|
SLAAVSQSLA
|
|
TRDDISVEAL
|
| QEQLTSVVQE
|
|
IGHLIDPIAT
|
|
AARGEAAQLG
|
|
HKVTQLASYF
|
|
EPLILAAVGV
|
| ASKILDHQQQ
|
|
MTVLDQTKTL
|
|
AESALQMLYA
|
|
AKEGGGNPKA
|
|
QHTHDAITEA
|
| AQLMKEAVDD
|
|
IMVTLNEAAS
|
|
EVGLVGGMVD
|
|
AIAEAMSKLD
|
|
EGTPPEPKGT
|
| FVDYQTTVVK
|
|
YSKAIAVTAQ
|
|
EMMTKSVTNP
|
|
EELGGLASQM
|
|
TSDYGHLAFQ
|
| GQMAAATAEP
|
|
EEIGFQIRTR
|
|
VQDLGHGCIF
|
|
LVQKAGALQV
|
|
CPTDSYTKRE
|
| LIECARAVTE
|
|
KVSLVLSALQ
|
|
AGNKGTQACI
|
|
TAATAVSGII
|
|
ADLDTTIMFA
|
| TAGTLNAENS
|
|
ETFADHRENI
|
|
LKTAKALVED
|
|
TKLLVSGAAS
|
|
TPDKLAQAAQ
|
| SSAATITQLA
|
|
EVVKLGAASL
|
|
GSDDPETQVV
|
|
LINAIKDVAK
|
|
ALSDLISATK
|
| GAASKPVDDP
|
|
SMYQLKGAAK
|
|
VMVTNVTSLL
|
|
KTVKAVEDEA
|
|
TRGTRALEAT
|
| IECIKQELTV
|
|
FQSKDVPEKT
|
|
SSPEESIRMT
|
|
KGITMATAKA
|
|
VAAGNSCRQE
|
| DVIATANLSR
|
|
KAVSDMLTAC
|
|
KQASFHPDVS
|
|
DEVRTRALRF
|
|
GTECTLGYLD
|
| LLEHVLVILQ
|
|
KPTPEFKQQL
|
|
AAFSKRVAGA
|
|
VTELIQAAEA
|
|
MKGTEWVDPE
|
| DPTVIAETEL
|
|
LGAAASIEAA
|
|
AKKLEQLKPR
|
|
AKPKQADETL
|
|
DFEEQILEAA
|
| KSIAAATSAL
|
|
VKSASAAQRE
|
|
LVAQGKVGSI
|
|
PANAADDGQW
|
|
SQGLISAARM
|
| VAAATSSLCE
|
|
AANASVQGHA
|
|
SEEKLISSAK
|
|
QVAASTAQLL
|
|
VACKVKADQD
|
| SEAMRRLQAA
|
|
GNAVKRASDN
|
|
LVRAAQKAAF
|
|
GKADDDDVVV
|
|
KTKFVGGIAQ
|
| IIAAQEEMLK
|
|
KERELEEARK
|
|
KLAQIRQQQY
|
|
KFLPTELRED
|
|
EG
|
Кодований геном білок за функцією належить до фосфопротеїнів.
Локалізований у клітинній мембрані, цитоплазмі, цитоскелеті, мембрані, клітинних контактах, синапсах.
Література
Примітки
Див. також
